Overview:
Rybelsus® 14 mg is a once-daily oral GLP-1 receptor agonist containing semaglutide, used to improve blood sugar control in adults with type 2 diabetes mellitus. It is the highest available dose in the Rybelsus titration regimen and is intended for patients who require additional glycemic control beyond the 7 mg dose.
Key Details:
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Active Ingredient: Semaglutide 14 mg
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Form: Oral tablet
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Therapeutic Class: GLP-1 receptor agonist
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Indication: Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes
Intended Use:
Rybelsus 14 mg is typically prescribed after patients have tolerated and responded to the 7 mg dose for at least 30 days, and need further improvement in blood glucose levels. It may be used alone or in combination with other diabetes medications, except for other GLP-1 receptor agonists.
How It Works:
Semaglutide mimics the action of the naturally occurring GLP-1 hormone, promoting insulin secretion, reducing glucagon release, and slowing gastric emptying. These combined actions help reduce postprandial and fasting blood glucose levels.
Dosage & Administration:
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Take one 14 mg tablet once daily, on an empty stomach
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Use with up to 4 oz (120 mL) of plain water only
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Wait at least 30 minutes before eating, drinking, or taking any other medications
Key Benefits:
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Oral GLP-1 therapy—no injections required
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Helps significantly reduce HbA1c levels
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May contribute to weight loss in some patients
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Convenient once-daily oral dosing
Safety Information:
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Not for use in patients with type 1 diabetes or for treating diabetic ketoacidosis
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Contraindicated in individuals with a personal or family history of medullary thyroid carcinoma (MTC) or MEN 2
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Common side effects: nausea, vomiting, diarrhea, abdominal discomfort, and loss of appetite
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Increased risk of hypoglycemia when used with insulin or sulfonylureas
Storage Instructions:
Store at room temperature: 20°C to 25°C (68°F to 77°F). Protect from moisture. Keep in original packaging until use.
Important Note:
Rybelsus 14 mg should only be used under the guidance and prescription of a licensed healthcare provider.
